Exchange database back up error 'Replica is Inconsistent'

I am running exchange 2013 with DPM protection. The exchange database is mounted and running fine, it is however generating a rapidly growing list of E02**.log files. on the exchange server. I am running a full backup through DPM on the volume disk and also the database itself. The database is returning a 'Replica is inconsistent' error.

I have transferred eseutil.exe and ese.dll files from exchange server to Dpm server location.

I have ran a consistency check on the database within DPM. I have tried re-creating the protection group but to no avail.

Any ideas on how to resolve the 'replica is inconsistent' error?

Thanks